Abstract

ADVANCES IN HCV TREATMENT-EFFECT OF HCV INFECTION/HCV TREATMENT (PEG-IFN/RIBAVIRIN) ON FERTILITY (OVARIAN RESERVE)

Highlights

  • Hepatitis C Virus (HCV) is a small enveloped, single stranded RNA virus of the Flaviriridae family[1]

  • To study the effects of HCV antiviral therapy on ovarian reserve Midan et al carried out a prospective longitudinal study where they examined 50 patients receiving either pegylated interferon [PEG IFNα2a or PEGIFNα2b plus ribavirin for a total of 48 weeks

  • Till 2001 - 2011 common treatment for chronic HCV infection was a combination of Pegylated Interferon (PEG-IFN) and ribavirin (RBV)

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Summary

Introduction

Hepatitis C Virus (HCV) is a small enveloped, single stranded RNA virus of the Flaviriridae family[1]. Englert et al studied the impact of seropositivity with HCV virus on IVF outcome in a retrospective study, where they found a statistically significantly absence of ovarian response in HCV seropositive women as compared with controls 10/42 vs 5/84 cycles, respectively. For cycles with oocyte retrieval HCV seropositive women required more gonadotropin units as compared to controls.

Results
Conclusion

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