Abstract
Renal cell carcinoma (RCC) is the most common type of kidney cancer in adults, it represents 90-95% of neoplasms arising from the kidney. The Xp11.2 RCC translocation is a subtype of RCC that is defined by different translocations involving the Xp11.2 chromosome, all of which result in transcription factor E3 (TFE3) gene fusions. We presented 2 adult cases of Xp11-RCC, one patient had lymph node metastases and the second patient also had liver metastases. Both patients improved with surgical treatment by radical total nephrectomy with lymph node dissection, in addition to neoadjuvant medical treatment.
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