Abstract
A patient with adult agammaglobulinemia characterized by recurring pyogenic infections, sprue-like syndrome, and reticuloendothelial hyperplasia of spleen and lymph nodes with granuloma formation, was found to have multiple congenital anomalies. This association is taken to favor the possibility that such adult “acquired” agammaglobulinemia may, in fact, represent another congenital anomaly. A hereditary basis is suggested by the presence of hypergammaglobulinemia in both parents.
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