Abstract
AbstractThe adsorption of five widely used 1. 4-benzodiazepines on talc, calcium phosphate, magnesium stearate, microcrystalline celluloses, ethyl cellulose and starch was studied. Adsorption of these compounds on charcoal was also investigated for comparison. Diazepam was found not to be adsorbed on talc, calcium phosphate and magnesium stearate. A relatively low adsorption of the drug by cellulose and starch was measured. The amount of diazepam adsorbed per unit weight of ethyl cellulose was high in water and in phosphate buffer, while no adsorption could be measured in 0.1 N HCL. The drug interact with ethyl cellulose at higher concentrations (100-180 mcg/ml). The UV and IR of the reactants and products were studied.The adsorption of nordiazepam, nitrazepam, flunitrazepam and chlordiazepoxide onto ethyl cellulose and charcoal from their aqueous solutions was also studied. Diazepam and nordiazepam showed the highest adsorption on ethyl cellulose. The desorption of benzodiazepines from ethyl cellulose in...
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