Abstract
β-Adrenergic receptor blocking (β-blocking) drugs now have an established place in the elective and prophylactic treatment of many cardiac arrhythmias. In isolated preparations of heart muscle, these drugs inhibit spontaneous diastolic depolarisation and in high concentrations which are unlikely to have clinical relevance, they exhibit membrane-depressant properties. In intact animals and man they slow the rate of discharge of the sinus and ectopic cardiac pacemakers and increase the functional refractory period of the AV node. They also retard conduction, both anterograde as well as retrograde, in anomalous pathways of the heart.
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