ADOLESCENT GIRLS & PECULIARITIES OF AGE CHANGES IN VITAMIN D

Abstract

In recent decades the problem of human reproduction concerns scientists and practitioners around the world. Deterioration of humans reproductive health, which determines health and viability of modern and future generations is noticed by a wide range of scientific and societal experts. A number of scientific studies demonstrate an importance of vitamin D and how its deficiency influences the occurrence of pathological condition of the female body. Researches in peculiarities of vitamin D level age changes of adolescent girls enable the development of algorithm|, which may help to prevent womens` reproductive system disorders.The aim of a study is the assessment of vitamin D levels in terms of age in adolescent girls. Materials and methods To perform the task of the study, we analyzed 1098 indicators of the level of 25 (OH) D, determined by enzyme-linked immunosorbent assay (ELISA), in the serum of adolescent girls aged from 10 to 18 years. Age distribution: 10 yo. — 102 (9,3%), 11 yo. — 100 (9,1%), 12 yo. — 115 (10,5%), 13 yo. — 103 (9,4%), yo. — 150 (13,6%), 15 yo. — 123 (11,2%), 16 yo. — 137 (12,5%), 17 yo. — 132 (12,0%), 18 yo. — 136 (12,4%). Statistics were processed with the help of Statistics 6.1. The distribution of indicators was checked using the Kolmogorov-Smirnov criterion. To describe the indicators, with a distribution other than Gaussian, the median and quartiles were used (Me, IQR: Q1-Q3). Describing the frequency characteristics the frequency (P)was used or (P ± 95% CI), where CI is a confidence interval. The Mann-Whitney test (U) was used to compare the two independent groups. Frequency comparisons were performed using conjugation tables.Results Analysis of the results for the level of 25- (OH) D in the serum of adolescent girls showed that the rate of the indicator (more than 75 nmol / l) was observed in 25.5 ± 2.6% (280/1098), the deficit of the indicator (less than 50 nmol) / l) was recorded in 32.1 ± 2.8% (352/1098), insufficiency in 42.4 ± 2.9% (466/1098) of persons. The percentage of normal vitamin D decreased from 10 - 11 years (28.4 ± 8.8 - 32.0 ± 9.1%) to 18 years (19.1 ± 9.9%). At the same time, the deficiency of the metabolite 25- (OH) D was statistically significant (χ22 = 9.0; p = 0.003) increased from 20.0 ± 7.8% in 11-year-old girls to 38.2 ± 8.2% by 18 years . The risk of 25- (OH) D deficiency in the 18-year-old population is 1.9 times higher than in eleven-year-olds (RR = 1,91; 95% CI: 1.2 - 3.0).Conclusions Favorable impact of developing a program for a healthy lifestyle in adolescent girls, active prevention and timely treatment of vitamin D deficiency and deficiency will have a positive effect on maintaining the reproductive health of girls and reduce the risk of obstetric and gynecological pathology in women.