Abstract

It has been shown by several investigators that preoperative administration of viosterol or irradiation, which presumably accomplishes the same ultimate result, will protect dogs to some extent against parathyroid tetany. Attempts to apply this method in the treatment of human postoperative tetany have not been so successful.The successful administration of viosterol intravenously to normal dogs in this laboratory suggested the trial of this method clinically.A woman, age 57, underwent a thyroidectomy and developed severe tetany within 2 days. During the next 6 months, the only treatment which consistently kept her free from tetany was calcium lactate by mouth with parathormone 2 or 3 times a week. Of the first she required approximately 115 gm. daily. Even this treatment, while maintaining her free from tetany did not render her normal. Full details of her clinical condition will be reported later.After preliminary observations, viosterol was injected intravenously in 0.5 cc. amounts of 8000 D preparatio...

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