Abstract
The role of the cholecystokinin B (CCK(B))/gastrin receptor in the pancreatic response to a standard meal was investigated in the pig. Twenty-four pigs were prepared surgically for the collection of the pancreatic juice and an intravenous perfusion. On experimental days, the pigs were perfused with one of two CCK(B)antagonists (L-365,260 or PD 135156) or the vehicle for 2 hours. We offered them a standard meal 30 minutes after the beginning of the perfusion. The pancreatic secretion was collected for 4 hours starting 30 minutes before the perfusion. Its volume was recorded, and the protein concentrations were assayed. Neither antagonist totally abolished the postprandial peak of the pancreatic protein. We suggest that the stimulation of pancreatic protein secretion by a meal is not mediated by CCK(B)/gastrin receptors. Because we previously showed that the CCK(A)receptor antagonist MK329 was no more able to abolish this response, CCK is probably not responsible for this response.
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