Abstract

Purpose: Osteoarthritis (OA) results in progressive cartilage destruction leading to joint malfunction. Current treatments, mostly symptomatic, are not able to stop or retard the progression of the disease. Hydrogen sulphide is a small gaseous molecule that has shown to prevent cartilage degradation as well as to exert antiinflammatory effects in in vitro models of OA, and is the active component of sulphurous minero-medicinal waters. The purpose here was to evaluate the effects of administering an H2S-producing compound, intra-articularly, in an experimental model of OA.

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