Abstract
The effect of intrathecal (IT) injection of glycine alone or in combination with 2-amino-5-phosphonopentanoate (AP5) on two nociceptive tests—the vocalization threshold to tail-shock (VTTS) and the tail-flick latency (TFL)—was studied in ovariectomized Sprague-Dawley rats. IT injection of 400 μg glycine induced a nonsignificant decrease, that is, in comparison with saline, in both nociceptive threshold. IT AP5 (10 μg) provoked a slight but significant increase in both nociceptive thresholds within the first 15 min postinjection. Combination of both glycine (400 μg) and AP5 (10 μg) produced marked and prolonged analgesia in both tests, which was significantly different from that obtained with AP5 alone. The results suggest that IT glycine acting through the strychnine-sensitive Gly 1 receptor produces analgesia provided its effect on the Gly 2 receptor linked to the NMDA receptor is prevented by an antagonist.
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