Abstract
To evaluate the effectiveness of the addition of recombinant LH(rLH) or Growth hormone (GH) to the antagonist protocol cycles in poor responders undergoing IVF( In Vitro Fertilisation ) Single centre prospective randomised control trial at a tertiary care infertility centre from 1st April 2017 to 30th March 2018. One hundred and twenty poor responder patients selected as per Poseidon Group 3 and 4 for IVF were enrolled the study and were randomly divided into two groups. Group A (n = 64) received rLH (75 IU)+rFSH (225 IU) from Day 2 (D 2) of cycle with addition of GnRh antagonist from D 6 and group B (n = 56) received GH (4 IU)+rFSH (225 IU) from D 2 with addition of GnRh antagonist from D 6 . The primary outcome measured was pregnancy rate. The secondary outcomes measured were number of oocytes retrieved, number of embryos formed and miscarriage rates. The number of retrieved oocytes was significantly higher in rLH/rFSH/GnRH antagonist group (Gp A) than GH/rFSH/GnRH antagonist group (Gp B), 9.35 ± 3.09 vs. 6.58 ± 2.91(p = 0.002) and the number of obtained embryos was also significantly higher in rLH/rFSH/GnRH antagonist group than GH/rFSH/GnRH antagonist group, 6.96 ± 2.82 as compared to 4.08 ±1.72 (p <.001). There were no significant differences between these group A & B regarding implantation, clinical pregnancy and miscarriage rateTabled 1Comparison of means for number of oocytes retrieved and number of embryos formedVariablesTherapyNumber of patientsMeanStd. DeviationStd. ErrorUnpaired t-test p-valueNumber of oocytes retrievedrLH649.353.0980.6070.002GH566.582.9140.572Number of embryos formedrLH646.962.8210.553<0.001GH564.081.7190.337 Open table in a new tab Addition of recombinant LH in antagonist protocol in poor responder patients significantly increased number of oocytes retrived and embryos formed when compared to addition of Growth hormone but there was no difference in pregnancy rates between the two groups.
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