Adjustment of gut hormones release pattern following a fixed mealtime change in human

Abstract

BackgroundGut hormones secretion is related to habitual mealtimes. However, how fast gut hormones adjust to that change when people change their fixed mealtime remains unknown. MethodsSeven healthy male volunteers were asked to eat a test breakfast at 0700am for 2weeks before the start of the study. Then, their fixed mealtime was intentionally changed from 0700am to 0900am for next 2weeks. Blood samples were drawn every half hour from 0500am until next 3h after breakfast for determining gut hormone levels every week. ResultsAfter a change in fixed mealtime, the release pattern of acylated ghrelin was first adjusted identically according to the change and then total ghrelin was made. The meal-related fluctuations of acylated ghrelin were delayed by 120min from week 1 after the change, while those of total ghrelin were delayed by 60min at week 1, by 120min at week 2. Two weeks was not enough time to adjust completely for PYY3–36 to the change. ConclusionTwo weeks is enough time until the pattern release of ghrelin, but not PYY3–36 , is adjusted fully after a fixed mealtime change in human.