Abstract
With an escalating incidence of breast cancer cases all over the world and the deleterious psychological impact that mastectomy has on patients along with several limitations of the currently applied modalities, it's plausible to seek unconventional approaches to encounter such a burgeoning issue. Breast tissue engineering may allow that chance via providing more personalized solutions which are able to regenerate, mimicking natural tissues also facing the witnessed limitations. This review is dedicated to explore the utilization of adipose tissue-derived mesenchymal stem cells for breast tissue regeneration among postmastectomy cases focusing on biomaterials and cellular aspects in terms of harvesting, isolation, differentiation and new tissue formation as well as scaffolds types, properties, material-host interaction and an in vitro breast tissue modeling.
Highlights
ProcedureIt involves harvesting and relocating adipose tissue to reconstruct the breast without using a scaffold and is considered as a limitless source for reconstructing soft tissues
Another method to reduce mortality associated with the reoccurrence potential of breast cancer, could involve malignant growth detection via chemicals within the scaffolds
Epithelial cells survival, proliferation, differentiation, polarity and invasive capacity are governed by cell–cell and cell–microenvironment interactions
Summary
It involves harvesting and relocating adipose tissue to reconstruct the breast without using a scaffold and is considered as a limitless source for reconstructing soft tissues. On the other hand, provide the option of more predictable physical and biological cell-material interactions as well as a better control over structural properties like porosity, density and degradation They are far from resembling the natural external environment with its essential triggering potentials for tissue engineering purposes [48,65]. Several attempts of constructing hybrid scaffolds containing both synthetic and natural components were made to enhance biological interactions such as directing cell migrations and facilitating cell mobility via natural secretion of proteases [66,67] Another successful example represents the modification of polyethylene glycol (PEG) acrylates with either arginine-glycine-aspartic acid peptide (a cell adhesive peptide) or with heparan sulfate (an ECM component) that were successfully incorporated within scaffolds to promote cellular attachment and allow reservation of heparan-binding growth factors [48]. The significant research efforts of Bissell group resulted in the development of 3D constructs using gel-based scaffolds, like Matrigel, collagen, Matrigel/collagen mix and laminin [18]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
