Abstract
Our knowledge of A1 and A2ARs has grown dramatically since they were first defined by Burnstock. With the recent purification of the A1AR and the cDNA cloning of the A2AR, an even more rapid expansion of information regarding their structure, function, and regulation should now ensue. We may then be able to return to the intact cell and organ system and better understand the physiological role of these ubiquitous receptors.
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