ADENOSINE DEAMINASE ACTIVITY IN PATIENTS WITH ANKYLOSING SPONDYLITIS

Abstract

Although the pathogenesis of ankylosing spondylitis (AS), which is a systemic disease characterized by inflammation, is largely unknown, pro-inflammatory mediators, oxidative stress, and immunity are thought to be involved in the development and the prognosis of the disease. It was aimed in this study to reveal activities of adenosine deaminase (ADA), a cornerstone enzyme in different pathways. Twenty nine AS patients and 16 healthy volunteers were included in the study. Patients were divided into two groups as active and inactive phases. Additionally, the patients were re-grouped according to axial/peripheral involvement. ADA and myeloperoxidase (MPO) activities, and advanced oxidation protein products (AOPP) levels were measured in plasma of the study groups. While the significant increases were observed in AOPP and MPO levels in AS patients compared to the control group, when the patients were divided into subgroups, only ADA was significantly decreased in active patients. On the other hand, there was no significant difference in AOPP, MPO, and ADA levels in groups created according to axial/peripheral involvement. Based on these findings, it is thought that the decrease in ADA levels in AS patients can give an idea about the prognosis of the disease and can be used as an activity marker. Keywords: Adenosine deaminase, advanced oxidation protein products, ankylosing spondylitis, autoinflammation, myeloperoxidase.