Abstract
Addition of Clonidine in Caudal Anesthesia in Children Increases Duration of Post-Operative Analgesia
Highlights
Pain in infancy is a developmental process
In this study we examined the duration of post-operative analgesia in children when clonidine is added to bupivacaine in caudal anesthesia
Implication for health policy/practice/research/medical education: The results of this study showed post-operative pain management in pediatric patients was enhanced when clonidine was added to the drug regimen
Summary
Pain in infancy is a developmental process. Due to the underdeveloped pain pathways in the spinal cord, the threshold of stimulation and sensation of pain is low at birth and has potential impacts on increasing the central effects of pain. Objectives: In this study we examined the duration of post-operative analgesia in children when clonidine is added to bupivacaine in caudal anesthesia. Children were randomly divided into 2 groups in a double-blind fashion, and were given caudal anesthesia with 0.125% bupivacaine (1ml/kg) alone or b bupivacaine plus 2 μg/kg clonidine. Results: Duration of analgesia was found to be significantly longer in the group given bupivacaine plus clonidine (mean 417.50 min vs 162.00 min). Conclusions: We concluded that addition of clonidine to bupivacaine prolongs the duration of post-operative analgesia without any respiratory or hemodynamic side-effects. Lack of pain management in children can result in morbidity and mortality (2). Addition of Clonidine in Children Increases Duration of Post-Operative Analgesia. Pain management protocols that use one type of pain reliever aiming to control one of the pathways of pain perception are usually less effective compared to those that use a combination of analgesics with the aim of controlling several pain pathways
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