Abstract
Swine subjected to 2weeks of repetitive pressure overload (RPO) exhibited significant myocyte loss, but leftventricular (LV) systolic function was preserved, and chamber dilatation did not occur. Instead, myocardialremodeling characterized by myocyte hypertrophy and interstitial fibrosis led to a marked reduction in LV diastolic compliance, which protected the heart from stretch-induced myocyte injury and preserved LVejection fraction without anatomic LV hypertrophy. These results support a novel paradigm that links cardiacadaptations to RPO with the pathogenesis of reduced LV diastolic compliance and may explain howLVstiffening can occur in the absence of sustained hypertension or anatomic hypertrophy.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
