Abstract
The mode of adaption in adult rats subjected to 50% energy restriction was studied. Basal O 2 consumption decreased by 17%, the magnitude of increase in O 2 consumption over basal level, in response to norepinephrine (NE) stimulation decreased by 45%. interscapular brown adipose tissue (IBAT) mass decreased by 30%. The specific activity of oubain sensitive ATPase increased in liver by 35% but not in kidney. The ouabain insensitive ATPase activity decreased in muscle was unaltered in the restricted rats. The mitochondrial respiration rates were unaltered. The total body fat content in the restricted rats decreased by 35% and the total protein content decreased by 8% compared to the initial value. The control rats had put on 30% more weight whereas the restricted rats lost 23% of the initial weight. Although alterations in the above parameters do indicate the mode of adaptation to underfeeding in adult rats, most of the observed changes in biochemical parameters however do not help in understanding the underlying mechanisms.
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