Abstract
Objective To investigate the efficacy and mechanism of acyclovir combined with dexamethasone for the treatment of herpes simplex virus encephalitis in mice.Method BALB/c mice were randomized into normal control group,model group,acyclovir monotherapy group and acyclovir combined with dexamethasone treatment group.Since the first day after modeling,mice in the acyclovir group and combined treatment group administered acyclovir by garage,normal control group and model control group received normal saline,since the third day after modeling,the combined treatment group given dexamethasone by intraperitoneal injection,other groups received saline intraperitoneally.The administration continued until the seventh day after modeling.The neurological symptom score and protein expression of nuclear transcription factor-κB and tumor necrosis factor-α were measured on the third,fifth and seventh day after modeling,the cumulative probability of mice survival were analyzed for 12 days.Results 7 days after modeling,neurological symptoms score of model group was highest of all,that of the combined treatment group was the lowest,the acyclovir group was in the middle,there was significant differences (P ＜ 0.05) between any two groups.12 days after modeling,all the mice in the model group died,survival rate of combined treatment group was significantly higher than that of acyclovir group.7 days after modeling,the protein expression level of nuclear transcription factor-κB and tumor necrosis factor-α of the model group were significantly higher than the normal control group,that of the acyclovir group and combined treatment group were significantly decreased,and there was statistically significant differences (P ＜ 0.05) between groups.Conclusion Acyclovir combined with dexamethasone in the treatment of mice with herpes simplex virus encephalitis could exhibited better effect than acyclovir monotherapy. Key words: Glucocorticoids; Active transport, cell nucleus; Tumor necrosis factor
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