Abstract
Acute pancreatitis is an inflammatory disease of the pancreas. Pancreatic necrosis is the most severe local complication because it is frequently associated with pancreatic infections. Alcohol abuse is the second most frequent causes of acute pancreatitis. Ethanol directly sensitises acinar cells to cholecystokinin stimulations. Acute pancreatitis develops in 10% of chronic alcohol abusers. Two cases are illustrative for the association of chronic alcohol abuse and acute pancreatitis with rapid fatal evolution.
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