ACUTE NON-INVASIVE CARDIAC OUTPUT MEASUREMENTS FOLLOWING CARDIAC RESYNCHRONIZATION THERAPY PREDICT LEFT VENTRICULAR REVERSE REMODELING AT 6 MONTHS AND LONG TERM SURVIVAL

Abstract

Abstract Category: 28. Cardiac PacingSession-Poster Board Number: 1089-397Authors: Fakhar Z. Khan, Munmohan S. Virdee, David Begley, John Hutchinson, Beverley Smith, Philip A. Read, Peter J. Pugh, Simon P. Fynn, David P. Dutka, Addenbrooke’s Hospital, Cambridge, United Kingdom, Papworth Hospital, Cambridge, United Kingdom Background: We aimed to assess to what extent acute changes in non invasive cardiac output measurements (NICOM) are related to longer term outcomes following cardiac resynchronization therapy (CRT).Methods: In 196 patients (69±9yrs, EF 23±7%, QRS 154±12ms, NYHA III/IV 183/13) CO recordings were made within 1 day of CRT at baseline (CRT OFF) and during optimized settings (CRT ON). Response was defined by >15% reduction in left ventricular end systolic volume (LVESV) at 6 months.Results: There was a significant difference in CO readings during CRT between responders (n=112) and non responders (6.23±1.21 vs 5.19±0.96L/min, p 20% in CO, 1 day after CRT implant had greater survival than those patients with <20% improvement (figure).Conclusions: NICOM recordings following CRT accurately predict LV reverse remodeling and long term survival. This validation study suggests potential use in either the optimization of CRT devices or in the guidance of LV lead placement.