Abstract
Rats, mice, beagle dogs, squirrel monkeys, and rhesus monkeys were exposed to various measured concentrations of monomethylhydrazine (MMH) vapor for specified time periods. Rodents were exposed for 30-, 60-, 120-, and 240-minute periods; dogs and squirrel monkeys, for 15, 30 and 60 minutes; and rhesus monkeys for 60 minutes only. The toxicity of MMH for the five animal species was defined by determinations of LC50 values, pathology, observations of responses, measurements of body weight in rats and mice, and blood chemistry and hematology tests on dogs, and rhesus monkeys. Squirrel monkeys proved to be the most sensitive and rats the least sensitive to the lethal effects of MMH. MMH exposure produced definite but transient, hemolytic changes in dogs and, to a lesser extent, in rhesus monkeys. These experiments show MMH to be a highly toxic compound.
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