Abstract
HDR brachytherapy is one of the effective approaches for safely delivering greater doses to the target, and has been used as a boost to EBRT for localized prostate cancer. We have reported the existence of a correlation between the severity of acute GU toxicity and the urethral dose in HDR brachytherapy using post-operative CT-based planning (Akimoto T et al., IJROBP 63, 2005 and IJROBP 64, 2005), and that the use of anatomy-based inverse optimization (IO) was associated with reduced incidence of grade 2 or worse acute GU toxicity compared to that of geometrical optimization, consistent with a reduction of the urethral dose (Akimoto T et al.
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