Acute fluctuation in blood glucose has no effect on platelet aggregation rate.

Abstract

Short-term acute blood glucose fluctuations are often found among patients with high risk of thrombosis. Influence of the phenomenon on platelet aggregation rate is of clinical importance and should be clearly evaluated. We measured ADP and arachidonic acid-induced platelet aggregation on 58 patients with type II diabetes or acute coronary syndrome before and after oral intake of 75 g of glucose. C-peptide and insulin levels were measured in diabetic patients and glycated hemoglobin was determined in ACS patients. Results showed that short-term acute glucose fluctuation had no significant impact on platelet aggregation in these patients. In diabetes patients, the 2 hours platelet aggregation rate induced by ADP was positively correlated with insulin levels (r = 0.477, p = 0.014). AA-induced platelet aggregation was positively correlated with BMI (r = 0.619, p = 0.024). In ACS cases, there was no correlation between platelet aggregation rates and glycated hemoglobin. There is probably no need to consider the possible influence of acute blood glucose fluctuation on thrombotic events.