Abstract
Abuse of anabolic-androgenic steroids (AAS) produces side effects in different tissues, with oxidative stress linked to their pathophysiology, being involved in fibrosis, cellular proliferation, and tumorigenesis. The aim of this study was to examine the acute effects of nandrolone decanoate (ND) on oxidative stress in isolated rat heart. The hearts of male Wistar albino were excised and perfused according to the Langendorff technique at gradually increasing coronary perfusion pressures (40-120 cmH2O). The hearts were perfused with ND at doses of 1, 10 and 100 μM. Oxidative stress markers, including the index of lipid peroxidation (thiobarbituric acid reactive substances (TBARS)), nitric oxide (nitrites; NO2-), the superoxide anion radical (O2-) and hydrogen peroxide (H2O2) were measured in the coronary venous effluent. Our results showed that acute effects of ND do not promote the production of reactive oxygen species (ROS). Our finding pointed out that the highest concentration of ND may even possess some anti-oxidative potential, which should be examined further.
Highlights
Anabolic-androgenic steroids (AASs) are synthetic derivatives of testosterone and are important pharmacologically for their use in the treatment of various medical conditions, such as growth deficiency, certain blood disorders, osteoporosis, hypogonadal dysfunction and the commencement of delayed puberty in men and growth promotion
The present study aimed to examine the effects of acute administration (1 μM, 10 μM, 100 μM) of nandrolone decanoate (Deca-Durabolin, DECA) on oxidative stress biomarkers in isolated rat hearts
reactive oxygen species (ROS) are normally produced by almost all cells of living organisms
Summary
Anabolic-androgenic steroids (AASs) are synthetic derivatives of testosterone and are important pharmacologically for their use in the treatment of various medical conditions, such as growth deficiency, certain blood disorders, osteoporosis, hypogonadal dysfunction and the commencement of delayed puberty in men and growth promotion. AASs have not always been used purely for medical purposes. Due to their anabolic effects, AASs became vastly popular among swimmers, weight lifters and both male and female professional athletes, recreational athletes, prepubescents and adolescents (Do Carmo et al, 2011; Tan et al, 1995). The use of AASs to enhance physical performance or appearance has greatly increased, and individuals usually administer doses that are 10 to 100 fold higher than the therapeutical dose. This abuse can cause many adverse effects (Yersalis et al, 1995). Little is known about influence of ND on different molecular interactions, such as the production of free radicals
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