Abstract
• Medial and lateral knee joint space (mm) in both hindlimbs were measured as a marker for the development of OA on all 30 mice every 6 weeks of their lifespan. Each mouse was anesthetized with isoflurane gas. The mouse was then shaved and ultrasound gel was applied to the medial and lateral aspect of both hindlimbs. Diagnostic ultrasound (SONOS 5500, Agilent Technologies, Andover MD) with a SONOS 15-6L ultrasound probe was utilized to image both hindlimbs (Figure 2). Once the medial and lateral joint lines were located, all joint space measures were made 1mm from the medial or lateral epicondyle. From this location, the distance from the medial or lateral condyle of the femur to the medial or lateral condyle of the tibia was measured to identify joint space for the respective hindlimb. INTRODUCTION METHODS RESULTS
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