Abstract
The effect of acute ethanol administration on pentylenetetrazole-induced c- fos expression in rat brain was studied. Pentylenetetrazole induced the rapid and transient expression of c- fos mRNA in rat brain. Maximal induction at a dose of 30 mg/kg was detected within 30 min and persisted for 60 min. Thereafter c- fos gene expression decreased to control levels by 180 min. No increase in c- fos mRNA was evident at doses of pentylenetetrazole ⩽ 20 mg/kg, whereas maximal elevation was seen at 30 or 40 mg/kg. This action was inhibited by acute ethanol treatment (blood alcohol level > 100 mg/dl). Acute ethanol treatment alone had no effect on c- fos gene expression.
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