Abstract
In the present work the cytosolic, membrane-bound and the total activities of brainsialidases were measured in fetal axonal growth cone particles and in various brain regions duringbrain development. The developmental profile showed an important activity in the prenatal andperinatal periods as well as in specific differentiating structures like the axonal growth cones fromthe fetal brain. Interestingly membrane-bound activity was higher than the cytosolic activity,starting from 50–60% at birth and increasing thereafter. Cytosolic activity was almost at adultlevels at birth and did not show a further significant increase thereafter. Our results stronglysuggest the commitment of membrane-bound sialidase activity in early neurodifferentiatingphenomena like axogenesis, probably regulating the turnover of glycoconjugates like gangliosidesat the presynaptic period, since high activity was observed in neuroblasts derived membranes andin the perinatal period.
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