Abstract
The active transport of iron has been studied further with everted gut sacs and loops of duodenum in the rat. The two-step absorptive mechanism appears to be one of the cellular processes which regulates iron absorption. A single dose of iron by mouth decreases both the net mucosal uptake and the net serosal transfer of iron, as studied with gut sacs in vitro. As little as 0.1 mg Fe is effective; the inhibition observed with 4.0 mg Fe persisted for approximately 17 hr. The reduction in transport appears to result, in part at least, from a direct effect of Fe on the intestine. The active transport mechanism also responds adaptively to the level of Fe in the diet. Late pregnancy increases the Fe transport, as observed with gut sacs in vitro and duodenal loops in vivo, and the effect is primarily on the serosal transfer step.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.