Abstract
The intestinal tract is the most rapidly renewed mammalian tissue and thus has highly active stem and transit-amplifying cells that promote renewal of terminally differentiated cells that perform digestive functions. Notch signaling is thought to act directly on stem cells to promote their proliferation and also in progeny precursors to determine absorptive versus secretory terminal differentiation pathways, although Notch signaling may actually enhance cell differentiation with other signaling pathways such as the Wnt-β-catenin pathway promoting cell proliferation.
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