Abstract
The effects of adenosine and of 2-chloroadenosine on the activity of platelet adenylate cyclase were measured using a particulate fraction from washed human platelets that had been lysed by freezing and thawing. At 25 μM these nucleosides increased activity to about 150–160% of the control value. Higher concentrations had less effect and adenosine was inhibitory above 100 μM. The activation was observed in the presence of papaverine or cyclic AMP but not aminophylline. In the presence of 1 μM PGE 1, which increased adenylate cyclase activity more than twelvefold, both nucleosides were inhibitory above 10 μM. The results suggest that the activation and inhibition of platelet adenylate cyclase by adenosine or 2-chloroadenosine are independent processes mediated by different components of a receptor-adenylate cyclase complex.
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