Abstract
IN several crayfish preparations1–5 γ-aminobutyric acid (GABA) mimics the natural inhibitory transmitter. Moreover, it has recently been found in large amounts in Cancer borealis peripheral nerve and muscle6, suggesting a possible role as inhibitory transmitter. The action of GABA on C. borealis muscle has not been examined. It has been reported that GABA has no inhibitory effect on C. anthonyi muscle7 and that it blocks excitatory junctional potentials in C. magister muscle while scarcely changing membrane conductance8. Thus, it seemed of interest to investigate the action of GABA on C. borealis muscle.
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