Abstract
Samples of 1 μl containing 15 μg of morphine sulfate with or without 1 μg of synthetic ACTH were injected into the fourth ventricle of rats. The inclusion of ACTH eliminated the analgesic effect of morphine as evaluated by the tail-flick test, both in restrained and in unrestrained, lightly sedated animals. The same result was obtained when β-endorphin was used to bring about analgesia. Since the effect of the peptides was shown to be mediated by central actions alone, the results are discussed in light of the brain ACTH/β-endorphin system.
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