Abstract
The acid mucopolysaccharides (MPS) were isolated from different organs from patients with primary and secondary amyloidosis, and the MPS composition of these tissues was compared with those isolated from control individuals. Although each organ contains different amounts and types of MPS, amyloid tissue in general shows an increase in total MPS, primarily due to heparitin sulfate. In the myocardium involved in primary (familial) amyloidosis (only one sample available for study), the increase in MPS is apparently due to hyaluronic acid, in contrast to liver, spleen, kidney, and heart tissue involved in secondary amyloidosis. A slight increase in chondroitin sulfate B was also noted in certain secondary amyloid tissues. The amino acid composition of peptide material bound to heparitin sulfate was determined, and no abnormality was observed from the similar MPS-protein complex isolated from control tissue.
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