Abstract
A long-acting, reversible acetylcholinesterase inhibitor, ambenonium chloride ( Mytelase), was added to developing cultures of neonatal mouse cerebellum to study its effect on myelin sheath formation. Myelinogenesis was inhibited completely in some cultures, retarded in others or apparently unaffected. The numbers of myelin sheaths per culture were also significantly reduced. Withdrawal of the compound resulted in the (re)initiation of myelinogenesis after 48 hr. The pattern of inhibition suggests that the acetylcholinesterase-containing neurons are the ones affected and supports the concept that the neuron may play an active role in the myelinogenetic process.
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