Abstract
Naphthalene, a Polycyclic Aromatic Hydrocarbon is widely used as a fumigant and disinfectant despite its toxic effect and is ranked as the ninth most threatening compound. The present study was carried out to determine the in vivo effect of naphthalene at different concentrations on acetylcholinesterase (AChE) enzyme activity in different tissues of Anabas testudineus. The fishes were exposed to varying concentrations of naphthalene (4.2 mgL–1, 4.4 mgL–1, 4.6 mgL–1, 4.8 mgL–1 and 5 mgL–1) for a period of 72 hours. Acetylcholinesterase enzyme activity was found to be significantly inhibited, in a dose-response manner. The inhibition percentage of AChE activity varied from 9.34–43.95% in brain tissue, 2.56–35.81% in liver tissue, 5.94–34.15% in muscle tissue and 3.92–33.75% in gills in comparison to the tissues of the control group. Maximum inhibition of acetylcholinesterase enzyme activity in treated fish was observed in the brain followed by liver, muscles, and gills. This study highlights the significance and role of acetylcholinesterase as a potential stress biomarker of naphthalene toxicity.
Highlights
Polycyclic Aromatic Hydrocarbons (PAHs), are the ninth most commonly distributed persistent organic pollutant group (POPs) capable of causing health hazards (Armstrong et al, 2004)
The average mean values of water quality parameters measured during the experiment were pH 7.56±0.10, temperature 22.60±0.39 °C, dissolved oxygen 5.12±0.57 mgL–1, total hardness 161.2±0.87 mgL–1 and alkalinity 146.4±0.76 mgL–1 (Table 2)
Naphthalene is a low molecular weight polycyclic aromatic hydrocarbon less sensitive to photooxidation, as a result it remains persistent in surrounding water leading to bio-accumulation over a period of time (Ansari et al, 2010)
Summary
Polycyclic Aromatic Hydrocarbons (PAHs), are the ninth most commonly distributed persistent organic pollutant group (POPs) capable of causing health hazards (Armstrong et al, 2004). PAHs comprise of carcinogenic and mutagenic forms and are included in the European Union and the United States Environmental Protection Agency (EPA) (Hossain et al, 2014; Latimer & Zheng, 2003). Constant discharge of these persistent organic pollutants into the aquatic ecosystem often leads to various contaminations and has been reported to affect the water quality. Biomarkers are measurable response signifying the first level of biological organization and have
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