Abstract
Background and aims. We aimed to replicate the previously observed association between acetylcholine receptor subtype M2 (CHRM2) gene polymorphisms and heart rate recovery (HRR) after exercise in patients with a recent acute myocardial infarction (AMI) and assess the prognostic significance of CHRM2 gene variants after AMI.Methods. HRR was determined as the difference between maximal heart rate and heart rate at 1 minute after the symptom-limited bicycle exercise test in 192 post-AMI patients. Genetic variants at the CHRM2 locus in intron 5 (rs324640) and the 3’-UTR of exon 6 (rs8191992) were assessed.Results. The rs324640 C/C and rs8191992 A/A homozygotes had more than a 3-fold risk of being in the lowest HRR quartile (≤ 8 bpm) compared to the T/T homozygotes (odds ratio (OR) 3.2, 95% confidence interval (CI) 1.2–8.6, P=0.017 and OR 3.8, 95% CI 1.3–11.1, P=0.016, respectively). In a larger sample of post-AMI patients (n=491), both C/C and A/A genotypes predicted cardiac mortality (11%) (adjusted relative risk (RR) 2.5, 95% CI 1.4–4.3, P=0.002 and RR 2.1, 95% CI 1.1–3.8, P=0.017, respectively) during a follow-up of 7.7±2.2 years.Conclusions. DNA sequence variation at the CHRM2 locus is a determinant of cardiac autonomic function in the postexercise early recovery phase and predicts cardiac mortality after AMI.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
