Acetals of lactams and amides. 42. Reactions of enamino amides and enamino esters with some formylating agents. Synthesis of derivatives of 2-pyridone and of pyrimidin-4- and -6-ones

Abstract

The reactions of enamino esters and enamino amides with the diethyl acetal of dimethylformamide and with orthoformic ester have been investigated and it has been shown that the process takes place in two directions — with the formation of pyrimidone or 2-pyridone derivatives and with the replacement of an aminopropylene (or N,N-dimethylaminopropylene) fragment of the enamine by a dimethylaminomethylene (or ethoxymethylene) group. Some conditions favoring the occurrence of one or other of these processes have been determined.