Abstract
BackgroundExperimental autoimmune neuritis (EAN) is a well-known animal model of human demyelinating polyneuropathies and is characterized by inflammation and demyelination in the peripheral nervous system. Fascin is an evolutionarily highly conserved cytoskeletal protein of 55 kDa containing two actin binding domains that cross-link filamentous actin to hexagonal bundles.MethodsHere we have studied by immunohistochemistry the spatiotemporal accumulation of Fascin + cells in sciatic nerves of EAN rats.ResultsA robust accumulation of Fascin + cell was observed in the peripheral nervous system of EAN which was correlated with the severity of neurological signs in EAN.ConclusionOur results suggest a pathological role of Fascin in EAN.Virtual slidesThe virtual slides for this article can be found here: http://www.diagnosticphatology.diagnomx.eu/vs/6734593451114811
Highlights
Experimental autoimmune neuritis (EAN) is an autoantigen-specific T-cell mediated inflammatory demyelinating disease of the peripheral nervous system (PNS), which is characterized by weight loss, ascending paraparesis/paralysis and spontaneous recovery [1]
EAN can be actively induced with peripheral nerve autoantigen and is pathologically characterized by breakdown of the blood-nerve barrier (BNB), robust accumulation of reactive T cells and macrophages into the PNS and demyelination of peripheral nerves [2]
Fascin expression in rat sciatic nerves of EAN rats were studied by IHC
Summary
Experimental autoimmune neuritis (EAN) is an autoantigen-specific T-cell mediated inflammatory demyelinating disease of the peripheral nervous system (PNS), which is characterized by weight loss, ascending paraparesis/paralysis and spontaneous recovery [1]. EAN can be actively induced with peripheral nerve autoantigen and is pathologically characterized by breakdown of the blood-nerve barrier (BNB), robust accumulation of reactive T cells and macrophages into the PNS and demyelination of peripheral nerves [2]. Th1 cells are activated by antigen-presenting cells (APCs) that are key players during both the initiation and progression of the autoimmune response. Experimental autoimmune neuritis (EAN) is a well-known animal model of human demyelinating polyneuropathies and is characterized by inflammation and demyelination in the peripheral nervous system. Virtual slides: The virtual slides for this article can be found here: http://www.diagnosticphatology.diagnomx.eu/vs/ 6734593451114811
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