Abstract
ScopeObservational studies have associated consumption of cruciferous vegetables with reduced risk of prostate cancer. This effect has been associated with the degradation products of glucosinolates—thioglycosides that accumulate within crucifers. The possible role of S‐methyl cysteine sulfoxide, a metabolite that also accumulates in cruciferous vegetables, and its derivatives, in cancer prevention is relatively unexplored compared to glucosinolate derivatives. The hypothesis that consuming a broccoli soup results in the accumulation of sulfate (a SMCSO derivative) and other broccoli‐derived metabolites in prostate tissue is tested.Methods and resultsEighteen men scheduled for transperineal prostate biopsy were recruited into a 4‐week parallel single blinded diet supplementation study (NCT02821728). Nine men supplemented their diet with three 300 mL portions of a broccoli soup each week for four weeks prior to surgery. Analyses of prostate biopsy tissues reveal no detectable levels of glucosinolates and derivatives. In contrast, SMCSO is detected in prostate tissues of the participants, with significantly higher levels in tissue of men in the supplementation arm. SMCSO was also found in blood and urine samples from a previous intervention study with the identical broccoli soup.ConclusionThe consequences of SMCSO accumulation in prostate tissues and its potential role in prevention of prostate cancer remains to be investigated.
Highlights
Scope: Observational studies have associated consumption of cruciferous association varies greatly between studies, with some studies suggesting convegetables with reduced risk of prostate cancer
S-methylcysteine sulfoxide (SMCSO) is detected in prostate tissues of the participants, with significantly higher levels in tissue of men in the supplementation arm
We investigate whether consuming a broccoli soup rich in 4-methylsulphinybutyl glucosinolate (“glucoraphanin”), the precursor of the isothiocyanate sulforaphane, and SMCSO can result in the accumulation of sulfate, the reported major derivative from SMCSO,[18] and other broccoli-derived metabolites in human prostate tissue
Summary
Scope: Observational studies have associated consumption of cruciferous association varies greatly between studies, with some studies suggesting convegetables with reduced risk of prostate cancer This effect has been sumption of four portions of cruciferassociated with the degradation products of glucosinolates—thioglycosides that accumulate within crucifers. Methods and results: Eighteen men scheduled for transperineal prostate biopsy were recruited into a 4-week parallel single blinded diet supplementation study (NCT02821728). Nine men supplemented their diet sides that are hydrolyzed by either plant or microbial-derived thioglucosidases to generate an array of biologically active compounds including isothiocyanates and indoles (Figure 1a,b).[6] The biowith three 300 mL portions of a broccoli soup each week for four weeks prior logical activities of these derivatives as to surgery. Cruciferous vegetables acfrom a previous intervention study with the identical broccoli soup
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