Abstract
Currently, the most used methods for adeno-associated viral (AAV) vector quantitative analysis are qPCR or ddPCR and ELISA assays, along with analytical ultracentrifugation (AUC) and transmission electron microscopy (TEM). The time to results when using these methods can range from days to several weeks, and the acceptable tolerance range is high. Rapid, reliable in-process testing offers a significant benefit to AAV downstream process development and can be achieved with Slope Spectroscopy® utilizing Variable Pathlength Technology (VPT). The CTech™ SoloVPE® System, when used at-line in one or more stages of a process, can help to quickly identify process characteristics, provide key insights, and allow for process optimization in minutes. VPT has enabled at-line measurement of concentration by eliminating the need for sample dilution or manipulation and delivering rapid and highly accurate real-time results.
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