Abstract
Flurbiprofen is a potent non-steroidal anti-inflammatory drug, prescribed commonly for musculoskeletal and joint disorders like arthritis. It is well established that drug degradation during storage and transportation is of particular issue in tropical countries like Pakistan, having areas with temperature variations from 0 o C (Muree, Islamabad, Sawat and Azad Jammu Kashmir) to 50 o C (Sibi, Jackababad, Nawabshah, Larkana, Multan and Bahawalpur) and some areas with high relative humidity (Karachi). Present study was designed to evaluate five different national brands of flurbiprofen 100 mg film coated tablets by accelerated stability studies and examined for the parameters of hardness, disintegration, dissolution and assay for drug concentration in formulation after one, three and six months duration at controlled tropical conditions of temperature and relative humidity. Dosage forms of all selected national brands were found stable even after expiry date.
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