Abstract
Abstract The spontaneously occurred lymphomas in SJL/J mice have many pathological features similar to Hodgkin’s lymphoma in human. The malignant growth of the tumor cells is dependent on the support of host FoxP3+ CD4+ regulatory T cells (Tregs). In this study, we report that the golli protein, a negative regulator of CRAC (calcium release activated calcium) channel in T cells, plays a critical role in the tumorigenesis of Hodgkin’s-like lymphoma. The ablation of golli protein in SJL/J mice results in an accelerated progression of Hodgkin’s-like lymphoma which is associated with a facilitated induction of FoxP3+ Treg cells. Our results suggest that through regulating the induction of Treg cells, golli protein affect the progression of Hodgkin’s-like lymphoma.
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