Abstract

Epigenetic clocks use CpG DNA methylation (DNAm) to estimate biologic age; acceleration is associated with diabetes mellitus (DM), heart disease, and shorter life. It is unknown if DNAm age is also related to cardiometabolic outcomes in pregnancy. AgeAccelGrim is a novel epigenetic clock that combines 7 DNAm components. We sought to determine if AgeAccelGrim is associated with obstetric metabolic syndrome.

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