Abstract
ObjectiveTo study which factors affect perinatal outcomes in intracytoplasmic sperm injection (ICSI) cycles.MethodsData was obtained from 402 live births born to 307 patients undergoing ICSI cycles in a private university-affiliated IVF center between Jan/2014 and Dec/2015. The influences of the cycles' characteristics on the number of gestational weeks to livebirth (GW), baby birth weight (BW), and baby birth length (BL) were evaluated by linear regression models, adjusted for maternal age and body mass index, number of transferred embryos, number of gestational sacs, and number of born infants. In a subsequent analysis, GW, BW and baby sex were utilized for cycle classification into the groups Appropriate for gestational age (AGA n=256) and Small for gestational age (SGA n=146), which were compared by general linear models adjusted for the same confounder variables.ResultsThe number of follicles (β=-0.069 p=0.018) and retrieved oocytes (β=-0.087 p=0.049) were negatively correlated with BL. The endometrial thickness was positively correlated with GW (β=0.198 p=0.003) and BW (β=28.351 p=0.044). When each baby was classified into AGA and SGA groups, it was observed that SGA babies were derived from cycles with higher estradiol levels at hCG day (SGA: 3897.01±550.35 vs. AGA: 2324.78±101.86 p=0.006) and higher number of retrieved oocytes (SGA: 16.70±1.78 vs. AGA: 12.92±0.42 p=0.042). The endometrial thickness was significantly lower in the SGA group (SGA: 10.27±0.23 vs. AGA: 11.68±0.17 vs. p=0.029).ConclusionHigher ovarian response to stimulation and suboptimal endometrial development are associated with adverse perinatal outcomes in ICSI cycles.
Highlights
gestational weeks to livebirth (GW), birth weight (BW) and baby sex were utilized for cycle classification into the groups Appropriate for gestational age (AGA n=256) and Small for gestational age (SGA n=146), which were compared by general linear models adjusted for the same confounder variables
Our findings suggest patients presenting any infertility factor, except unexplained infertility, are suitable to receive a single embryo transfer (SET) with satisfactory outcomes
The aim of our study was to identify the prevalence of Human Papillomavirus (HPV) in the semen of men submitted to assisted reproductive technique (ART) treatment and to identify the possible impact of the virus in spermatic parameters
Summary
The final stage of assisted reproductive technique (ART), is a crucial step in ensuring successful in vitro fertilization (IVF) cycles. The objective of the present study was to determine the influence of the embryo placement depth on the endometrial cavity in relation to the reproductive outcomes, after frozen-thawed embryo transfer of embryos performed under transabdominal ultrasound guidance. Methods: Retrospective cohort study that evaluated the influence of the placement depth of the embryos in the endometrial cavity in relation to reproductive outcomes of patients submitted to cryotransfer cycles at a private assisted reproduction clinic, from 2012 to 2017. Results: Clinical and ongoing pregnancy rates were higher in the groups 10-15mm and >15mm, when compared to the group 10mm
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