Abstract
Table of contentsO1 Changes in peripheral refraction associated with decreased ocular axial growth rate in marmosetsAlexandra Benavente-Perez, Ann Nour, Tobin Ansel, Kathleen Abarr, Luying Yan, Keisha Roden, David TroiloO2 PPARα activation suppresses myopia development by increasing scleral collagen synthesis--a new drug target to suppress myopia developmentChanyi Lu, Miaozhen Pan, Min Zheng, Jia Qu, Xiangtian ZhouO3 Evidence and possibilities for local ocular growth regulating signal pathwaysChristine F WildsoetO4 Myopia researches at Eye Hospital of Wenzhou Medical UniversityFan Lu, Xiangtian Zhou, Jie Chen, Jinhua Bao, Liang Hu, Qinmei Wang, Zibing Jin, Jia QuO5 Color, temporal contrast and myopiaFrances Rucker, Stephanie Britton, Stephan Hanowsky, Molly SpatcherO6 The impact of atropine usage on visual function and reading performance in myopic school children in TaiwanHui-Ying Kuo, Ching-Hsiu Ke, I-Hsin Kuo, Chien-Chun Peng, Han-Yin SunO7 Increased time outdoors prevents the onset of myopia: evidence from randomised clinical trialsIan G MorganO8 Environmental risk factors and gene-environment interactions for myopia in the ALSPAC cohortJeremy A. Guggenheim, Rupal L. Shah, Cathy WilliamsO9 Retinal metabolic profiling identifies declines in FP receptor-linked signaling as contributors to form-deprived myopic development in guinea pigsJinglei Yang, Peter S. Reinach, Sen Zhang, Miaozhen Pan, Wenfeng Sun, Bo Liu, Xiangtian ZhouO10 The study of peripheral refraction in moderate and high myopes after one month of wearing orthokeratology lensJun Jiang, Haoran Wu, Fan LuO11 Axial length of school children around the earth’s equatorial area and factors affecting the axial lengthKazuo Tsubota, Hiroko Ozawa, Hidemasa Torii, Shigemasa Takamizawa, Toshihide Kurihara, Kazuno NegishiO12 Processing of defocus in the chicken retina by retinal ganglion cellsKlaus Graef, Daniel Rathbun, Frank SchaeffelO13 Blue SAD light protects against form deprivation myopia in chickens, by local signaling within the retinaLadan Ghodsi, William K. StellO14 Contributions of ON and OFF pathways to emmetropization and form deprivation myopia in miceMachelle T. Pardue, Ranjay Chakraborty, Han na Park, Curran S. Sidhu, P. Michael IuvoneO15 Response of the human choroid to defocusMichael J CollinsO16 What can RNA sequencing tell us about myopic sclera?Nethrajeith Srinvasalu, Sally A McFadden, Paul N BairdO17 Overview of dopamine, retinal function, and myopiaP. Michael IuvoneO18 The eye as a "robust" optical system and myopiaPablo ArtalO19 Effect of discontinuation of orthokeratology lens wear on axial elongation in childrenPauline Cho, SW CheungO20 Myopia prevention in TaiwanPei-Chang WuO21 Alternatives to ultraviolet light and riboflavin for in vivo crosslinking of scleral collagenQuan V. Hoang, Sally A. McFaddenO22 Absence of intrinsically photosensitive retinal ganglion cells (ipRGC) alters normal refractive development in miceRanjay Chakraborty, Duk C. Lee, Erica G. Landis, Michael A. Bergen, Curran Sidhu, Samer Hattar, P. Michael Iuvone, Richard A. Stone, Machelle T. PardueO23 Scleral micro-RNAs in myopia development and their potential as therapeutic targetsRavi MetlapallyO24 Effects of the long-wavelength filtered continuous spectrum on emmetropization in juvenile guinea pigsRuiqin Li, Qinglin Xu, Hong Zhon, Chenglin Pan, Weizhon Lan, Xiaoning Li, Ling Chen, Zhikuan YangO25 Ocular and environmental factors associated with eye growth in childhoodScott A. ReadO26 Overview- prevention and prediction of myopia and pathologic myopiaSeang-Mei SawO27 New insights into the roles of retinal dopamine in form-deprivation myopia and refractive development in C57BL/6 miceShi-Jun Weng, Xiao-Hua Wu, Kang-Wei Qian, Yun-Yun Li, Guo-Zhong Xu, Furong Huang, Xiangtian Zhou, Jia Qu, Xiong-Li Yang, Yong-Mei ZhongO28 The effects of the adenosine antagonist, 7-methylxanthine, on refractive development in rhesus monkeysEarl L Smith III, Baskar Arumugam, Li-Fang Hung, Lisa A. Ostrin, Klaus Trier, Monica Jong, Brien A. HoldenO29 Application of SWATH™ based next generation proteomics (NGP) in studying eye growth: opportunities and challengesThomas Chuen Lam, Bing Zuo, Samantha Shan, Sally A. McFadden, Dennis Yan-yin Tse, Jingfang Bian, King-Kit Li, Quan Liu, Chi-ho ToO30 How could emmetropization make use of longitudinal chromatic aberration?Timothy J. Gawne, John T. Siegwart Jr., Alexander H. Ward, Thomas T. NortonO31 Balance effect of dopamine D1 and D2 receptor subtype activation on refraction developmentXiangtian ZhouO32 BMP gene expression changes in chick rpe in response to visual manipulationsYan Zhang, Yue Liu, Carol Ho, Eileen Phan, Abraham Hang, Emily Eng, Christine Wildsoet
Highlights
We applied gas chromatography-time of flight mass spectrum (GC-TOF) analysis to explore the retinal metabolic profile of form-deprived myopic guinea pigs at different time points in the hope of providing key information about metabolic changes contributing to myopia development
Conclusions wearing orthokeratology lens in the daytime can correct residual refractive errors for high myopes, it may result in the decrease of myopia defocus or even a hyperopic shift in Relative peripheral refractions (RPREs)
Based on the hypothesis of peripheral refraction theory for myopia control, the spectacles may be a better choice than the daily-wear orthokeratology lens for correcting residual refractive errors in high myopes
Summary
Juvenile tree shrews were placed in ambient light that varied in both chromatic content (red, 628 ± 10 nm, 325-700 human lux, or blue, 464 ± 10 nm, 241-500 human lux) and temporal profile (steady, or flickering with sharp transients to mimic what happens on the back of the retina as an animal moves around: broadband from DC to over 100 Hz). The red light only excited LWS cones; the blue light excited SWS cones 1.56 times more strongly than the LWS cones. Refractive state was measured, often daily, with a Nidek autorefractor while the animals were awake. Axial component dimensions were measured with a LenStar optical biometer in awake animals at key points during the experimental period
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