Abstract
Background: Post-stroke dementia is an important factor of poor functional outcome following stroke. However, few longitudinal studies on the incidence and risk factors of dementia after stroke have been performed. Hypothesis: We aimed to investigate the incidence and clinical factors related to dementia after ischemic stroke. Methods: A total of 47,779 patients with acute ischemic stroke (within 7 days after stroke onset) were enrolled, who were registered in the Clinical Research Center for Stroke (CRCS) registry from 2006 to 2014 and successfully linked the Health Insurance Review and Assessment Service (HIRA) big database. All included patients did not have dementia before index stroke. The incidence of post-stroke dementia was identified using International Classification of Diseases, Tenth Revision, dementia diagnosis codes (F00, F01, F02, F03, and G30) with prescription of an anti-dementia medications after index stroke based on linked big data. Results: Of the 47,779 patients, 10,357 patients (21.7%) had post-stroke dementia. The cumulative incidence of dementia after stroke was 10.4% after 1 year, 15.6 % after 3 years, 19.5% after 5 years, 22.9% after 7 years, and 27.1% after 10 years. The crude incidence rate of post-stroke dementia was 40.03 cases per 1000 person-years in this stroke registry based linkage big data. Post-stroke dementia groups were older, more frequently female, and were more likely to have severe stroke, history of stroke, lower education level, dependency before stroke. Conclusions: Our study demonstrated that about 22% of ischemic stroke patients were demented after stroke, particularly were associated with history of stroke, and stroke severity. These patients with high risk of dementia should be controlled risk factors for preventing cognitive impairment following stroke.
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