Abstract
Abstract Metastastic spread has been difficult to study because it involves a series of rare events that are difficult to observe in vivo. To capture such events, we have employed lineage tracing - a technique which allows cells to be tagged and tracked - and applied it to an autochthonous mouse model of pancreatic cancer. Using this approach, found that pancreas-derived cells entered the circulation at the PanIN-stage, prior to the presence of a histologically recognizable tumor. Moreover, invasive behavior was almost universally associated with epithelial-to-mesenchymal transition (EMT), and bloodstream entry was associated with a “cancer stem cell” phenotype. These observations demonstrate that cellular dissemination in pancreatic cancer can occur at a very early stage of tumor progression. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr SY04-02. doi:1538-7445.AM2012-SY04-02
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