Abstract
Background & Objectives: Reveal the mechanism of general anesthesia induced loss of consciousness is crucial in the study of anesthetic effect[1-2]. Study found that neuronal activity and synaptic transmission can be regulated by a variety of neural active substance released from astrocytes, which participating in the brain information integration[3-4]. Astrocytes may take part in the general anesthesia induced loss of consciousness, however, there is no related report. Materials & Methods: This study chose the rats cortical astrocytes as the main object of observation, utilizing the brain slice patch clamp technique and calcium imaging to investigate the effects of three intravenous anesthetics (propofol, dexmedetomidine and ketamine) on astrocytes calcium ion excitatory and the information exchange between astrocytes and neurons. Results: Among three kinds of anesthetics, only ketamine inhibits ADP-induced calcium oscillations in astrocytes in a concentration dependent manner. Ketamine (220μM) inhibits astrocyte-induced slow inward current in rat cortical neuron.Conclusion: Our data provided experimental evidence proving astrocyte-related mechanism of central effects of ketamine.
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