Abstract P5-01-13: The spectroscopic feature of breast cancer

Abstract

Abstract Objectives: To examine optical properties of breast cancer by time-resolved spectroscopy. Materials and Methods: We irradiated a pulsed laser of 760, 800, and 830 nm wave-length lights at multiple sites of both breasts including the site just above the cancer and detected the light transmitted through the breast with TRS-20SH (Hamamatsu Photonics K.K.). Absorption coefficient (μa), reduced scattering coefficient (μs’), total hemoglobin (tHb), and oxygen saturation (SO2) of the breast were calculated by photon diffusion equation. The clinical trial started in January 2007. A total of one hundred fifty-two breast cancer patients participated in the trial and written informed consent were obtained from all of the patients. Results: The absorption coefficient (μa) in 760, 800 and 830 nm wave-length of breast cancer tissue was significantly high compared with contra-lateral normal breast (760nm:cancer;0.078 normal;0.063 p<0.001. 800nm cancer:0.071, normal;0.050, p<0.001. 830nm: cancer;0.084, normal;0.063, p<0.001). The absorption coefficient and reduced scattering coefficient between breast cancer tissue and contra-lateral normal breast μa (/cm)μs'(/cm) cancernormal breastcancernormal breast760nm0.0780.0639.589.71800nm0.0710.059.239.4830nm0.0840.0639.079.22 There was no difference in reduced scattering coefficient (μs’) between breast cancer tissue and contra-lateral normal breast(760nm: cancer;9.58, normal;9.71, 800nm: cancer:9.23, normal;9.40. 830nm; cancer;9.07, normal;9.22). The tHb of breast cancer tissue was significantly high, compared with normal breast (cancer:32.3±14.6, normal breast;22.0±8.6, p=0.001). There was no difference in oxygen saturation (SO2) between breast cancer tissue and contra-lateral normal breast (cancer:73.2±4.3, normal breast;73.6±5.9, p=0.31). The tHb and SO2 between breast cancer tissue and contra-lateral normal breast cancernormal breastp-valuetHb(μM)32.3±14.622.0±8.6p<0.001SO2(%)73.2±4.373.6±5.9p=0.32 Conclusion: Absorption coefficient (μa) and tHb increased in breast cancer, whereas reduced scattering coefficient (μs’) and oxygen saturation did not. Citation Format: Hiroyuki Ogura, Nobuko Yoshizawa, Kenji Yoshimoto, Hatsuko Nasu, Yumiko Taki, Youko Hosokawa, Ryouichi Matsunuma, Yoshimi Ide, Etsuko Yamaki, Toshihiko Suzuki, Motoki Oda, Yukio Ueda, Yutaka Yamashita, Harumi Sakahara. The spectroscopic feature of breast cancer [abstract]. In: Proceedings of the Thirty-Seventh Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2014 Dec 9-13; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2015;75(9 Suppl):Abstract nr P5-01-13.